Vasti karma is considered to be the main panchakarma therapy in which the accumulated toxins and vitiated dosha’s are expelled by medicated enema. It is a superior treatment methodology beneficial in chronic diseases. It is generally performed for diseases of vata predominance. It has multidimensional actions and is equally effective in lifestyle diseases, neuromuscular diseases, immune system diseases, infertility, geriatric problems etc. Kashaya Vasti, Sneha Vasti, Matra vasti and Utara vasti are the different vasti’s commonly practiced.